Research

Six interconnected research programmes spanning experimental and computational RNA biology.

Translation & RNA Stability

How do cells decide which messages to read, and when to destroy the script?

A ribosome moving along a messenger RNA and building a protein5′3′ribosome reads mRNA → protein

Epitranscriptome & Modifications

What happens when the cell edits its own genetic messages after they're written?

Chemical marks on a messenger RNA and the raw signal dips that reveal themm6Am5CΨm1Aac4Cchemical marks rewrite the message

Computational RNA Biology

Can we learn to understand the language of RNA?

Sequencing signal passing through a model and coming out as measurementsACGUUGlearning the language of RNA

Ageing & Stress Response

Why do our cells lose their ability to handle stress as we age?

Cells ageing as damage accumulates and stress response capacity fallsdamagecapacitycells lose their composure over time

RNA Therapeutics & Cancer

Can we reprogram cancer cells by rewriting their RNA instructions?

A designed messenger RNA packaged into a lipid nanoparticle and delivered to a cancer cellcarrierdesigned RNA targets disease

Treatment Optimisation

What if mathematical models could predict the best treatment for each patient?

A patient trajectory with a model whose uncertainty narrows at every measurementeach measurement sharpens the model